A “Neuroma” may occur when there is an injury to the nerve that travels between the smaller metatarsals. The nerve commonly becomes pinched due to tight or narrow shoes, it is common in a pronated foot that rolls inward, and the patients commonly has a loss of fat padding in the metatarsal area. This injury is more commonly seen in female patients, proving that women’s tight shoes are a big factor in the development of this condition. Men can experience this injury, too. So, as Dr. Schoene explains in Outside magazine, paying attention to your shoe size is very important. Shoe size can go up with increasing body weight, child birth, continual prolonged standing or years of athletic activities. It is important to make sure to have the feet measured each year for the proper width and length. Athletic shoes should always be larger than dress shoes.